Reliability and Accuracy of Peri-Interventional Stenosis Grading in Peripheral Artery Disease Using Color-Coded Quantitative Fluoroscopy: A Phantom Study Comparing a Clinical and Scientific Postprocessing Software

Table 1

Results of the ANOVA analysis for ROIs II to IV as analyzed with ImageJ. Percentage changes of contrast intensity curves (area under the curve) using four different integration times (1, 3, 5, and 7 seconds) are compared to a reference ROI 5 cm proximal to the stenosis (ROI I). Arithmetic mean, standard deviations, and p values (significant values are marked with an asterisk) of three repeated measurements are listed.

ROI	Integration times [seconds]	0% stenosis	40 % stenosis	60 % stenosis	80 % stenosis	p-value
II
	1s	-2.87% (±4.85%)	0.35% (±20.6%)	-0.71% (±8.16%)	-9.99% (±6.56%)	0.71
	3s	18.67% (±3.2%)	10.81% (±14.4%)	9.68% (±4.69%)	-2,73% (±4.09)	0.1
	5s	21.12% (±5.34)	11.8% (±17.03%)	10.57% (±11.93%)	-7.87% (±2.93%)	0.06
	7s	19.88% (±5.61%)	13.59% (±19.26%)	11.17% (±13.78%)	-11.07% (±2.92%)	0.06
III
	1s	-7.25% (±3.11%)	-12.64% (±20.74%)	-6.06% (±19.66%)	-20.83% (±6.13%)	0.62
	3s	26.06% (±3.41%)	11.73% (±10.22%)	10.73% (±4.39)	0.24% (±1.87%)	0.0048
	5s	29.75% (±4.34%)	7.84% (±11.3%)	8.49% (±1.37%)	-9.18% (±1.63%)	0.0004
	7s	28.09% (±5.65%)	5.5% (±12.78%)	7.59% (±0.97%)	-13.79% (±2.2%)	0.0007
IV
	1s	-13.39% (±9.4%)	-16.16% (±18.65%)	-19.03% (±26.63%)	-31.68% (±11.1%)	0.62
	3s	39.38% (±5.63%)	30.32% (±15.58%)	12.51% (±9.96%)	3.52% (±6.37%)	0.0094
	5s	46.78% (±8.27%)	25.94% (±15.81%)	9.89% (±6.81%)	-5.64% (±6.1%)	0.0012
	7s	46.75% (±9.57%)	23.33% (±17.65%)	8.22% (±4.69%)	-10.86% (±6.13%)	0.0011