Identification of the Key MicroRNAs and the miRNA-mRNA Regulatory Pathways in Prostate Cancer by Bioinformatics Methods

Table 2

Results of top 10 gene ontology (GO) categories and the top 5 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.

Category	Term	Description	Gene counts	P-value
Up-regulated gene
GO:0005515	MF	protein binding	416	1.40E-20
GO:0005654	CC	nucleoplasm	164	5.20E-14
GO:0044822	MF	poly(A) RNA binding	88	1.80E-12
GO:0005829	CC	cytosol	180	3.00E-12
GO:0005913	CC	cell-cell adherens junction	40	3.20E-12
GO:0098641	MF	cadherin binding involved in cell-cell adhesion	37	4.00E-11
GO:0070062	CC	extracellular exosome	153	2.50E-10
GO:0005634	CC	nucleus	252	3.10E-10
GO:0098609	BP	cell-cell adhesion	33	1.40E-09
GO:0005737	CC	cytoplasm	237	1.90E-08
hsa05215	KEGG	Prostate cancer	14	4.10E-05
hsa04350	KEGG	TGF-beta signaling pathway	11	1.80E-03
hsa05202	KEGG	Transcriptional misregulation in cancer	16	2.80E-03
hsa05210	KEGG	Colorectal cancer	9	3.00E-03
hsa04910	KEGG	Insulin signaling pathway	14	3.30E-03
Down-regulated gene
GO:0031012	CC	extracellular matrix	23	2.20E-10
GO:0009986	CC	cell surface	28	1.30E-08
GO:0005515	MF	protein binding	170	1.00E-07
GO:0005925	CC	focal adhesion	22	1.70E-07
GO:0030198	BP	extracellular matrix organization	16	2.30E-07
GO:0005578	CC	proteinaceous extracellular matrix	17	1.30E-06
GO:0007155	BP	cell adhesion	22	4.80E-06
GO:0045944	BP	positive regulation of transcription from RNA polymerase II promoter	34	8.30E-06
GO:0008201	MF	heparin binding	12	2.40E-05
GO:0030574	BP	collagen catabolic process	8	4.30E-05
hsa04668	KEGG	TNF signaling pathway	12	3.30E-06
hsa04510	KEGG	Focal adhesion	16	4.80E-06
hsa05205	KEGG	Proteoglycans in cancer	15	1.60E-05
hsa05144	KEGG	Malaria	7	2.50E-04
hsa04064	KEGG	NF-kappa B signaling pathway	8	1.00E-03

BP: biological process; CC: cellular component; MF: molecular function