Identification of the Key MicroRNAs and the miRNA-mRNA Regulatory Pathways in Prostate Cancer by Bioinformatics Methods

Table 3

The top 5% hub genes in the protein-protein interaction (PPI) networks.

Entrez Gene ID	Gene symbol	Full gene name	Degree
Up-regulated gene
3312	HSPA8	heat shock protein family A (Hsp70) member 8	40
5518	PPP2R1A	protein phosphatase 2 scaffold subunit Aalpha	32
1499	CTNNB1	catenin beta 1	25
8334	HIST1H2AC	histone cluster 1 H2A family member c	24
10921	RNPS1	RNA binding protein with serine rich domain 1	23
85236	HIST1H2BK	histone cluster 1 H2B family member k	22
8970	HIST1H2BJ	histone cluster 1 H2B family member j	22
5878	RAB5C	RAB5C, member RAS oncogene family	22
595	CCND1	cyclin D1	21
8301	PICALM	phosphatidylinositol binding clathrin assembly protein	21
25977	NECAP1	NECAP endocytosis associated 1	21
51429	SNX9	sorting nexin 9	21
8349	HIST2H2BE	histone cluster 2 H2B family member e	20
1026	CDKN1A	cyclin dependent kinase inhibitor 1A	20
Down-regulated gene
111	ADCY5	adenylate cyclase 5	12
301	ANXA1	annexin A1	11
1298	COL9A2	collagen type IX alpha 2 chain	10
1277	COL1A1	collagen type I alpha 1 chain	9