Use of a Radiomics Model to Predict Tumor Invasiveness of Pulmonary Adenocarcinomas Appearing as Pulmonary Ground-Glass Nodules
Table 1
Characteristics of patients for preinvasive lesions and IPAs.
All GGNs
Preinvasive lesions
IPAs
P value
(n=599)
(n=201)
(n=398)
Sex
M
171(28.5%)
57(28.4%)
114(28.6%)
0.942
F
428(71.5%)
144(71.6%)
284(71.4%)
Age
58.37±11.40
57.39±12.08
58.86±11.03
Smoking
0.137
yes
86(14.4%)
23(11.4%)
63(15.8%)
0.148
no
513(85.6%)
178(88.6%)
335(84.2%)
Symptom
yes
112(18.7%)
76(19.1%)
36(17.9%)
0.725
no
487(81.3%)
322(80.9%)
165(82.1%)
History of tumor
yes
44(7.2%)
17(8.5%)
27(6.5%)
0.393
no
555(92.8%)
184(91.5%)
371(935%)
Location
Right upper
248(41.4%)
94(46.8%)
154(38.7%)
0.445
Right middle
48(8.0%)
14(7.0%)
34(8.5%)
Right lower
85(14.2%)
25(12.4%)
60(15.1%)
Left upper
145(24.2%)
45(22.4%)
100(25.1%)
Left lower
73(12.2%)
23(11.4%)
50(12.6%)
Surgery
wedge resection
312(52.1%)
126(62.7%)
186(46.7%)
<0.01
segmentectomy
92(15.4%)
26(12.9%)
66(16.6%
lobectomy
195(32.5%)
49(24.4%)
146(36.7)
Density
pure
282(47.1%)
125(62.2%)
157(39.4%)
<0.01
mixed
317(52.9%)
76(37.8%)
241(60.6%)
Shape
Round or oval
363(60.6%)
150(74.6%)
213(53.5%)
<0.01
irregular
236(39.4%)
51(25.4%)
185(46.5%)
Bubble sign
yes
139(23.2%)
39(19.4%)
100(25.1%)
0.117
no
460(78.8%)
162(80.6%)
298(74.9%)
Air-bronchogram sign
yes
120(20.0%)
21(10.4%)
99(24.9%)
<0.01
no
479(80.0%)
180(89.6%)
299(75.1%)
Lobulated border
yes
223(37.2%)
26(12.9%)
197(49.5%)
<0.01
no
376(62.8%)
175(87.1%)
201(50.5%)
Spiculation sign
yes
94(15.7%)
19(9.5%)
75(18.8%)
<0.01
no
505(84.3%)
182(90.5%)
323(81.2%)
Clear margin
yes
527(88.0%)
171(85.1%)
356(89.4%)
0.120
no
72(12.0%)
30(14.9%)
42(10.6%)
Pleural retraction
yes
181(30.2%)
34(16.9%)
147(36.9%)
<0.01
no
418(69.8%)
167(83.1%)
251(63.1%)
Abnormal vessels
yes
302(50.4%)
88(43.8%)
214(53.8%)
0.021
no
297(49.6%)
113(56.2%)
184(46.2%)
Pathology
AAH
80 (13.3%)
29 (14.4%)
51 (12.8%)
0.567
AIS
121 (20.2%)
38 (18.9%)
83 (20.9%)
MIA
174 (29.2%)
65 (32.8%)
109 (27.4%)
IAC
224 (37.3%)
69 (33.9%)
155 (38.9%)
means P value is derived from the chi-square test and Student’s t-test between preinvasive lesions and IPAs. Note: AAH=atypical adenomatous hyperplasia, AIS=adenocarcinoma in situ, MIA=minimally invasive adenocarcinoma, IAC=invasive adenocarcinoma, and IPAs=invasive pulmonary adenocarcinomas.
