Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling

Figure 4

A lack of cyclin G2 promotes the activation of canonical Wnt signalling in a DN mouse model. (a) Representative western blots and (b) densitometry for β-catenin, cyclin D1, and MMP7 in the renal cortex of WT and Ccng2^−/− mice. (c) Representative western blots and (d) densitometry for β-catenin, cyclin D1, and MMP7 in the renal cortex of control WT and STZ-induced WT and Ccng2^−/− DN mice. (e) Representative β-catenin immunohistochemistry for control WT and Ccng2^−/− mice and STZ-induced WT and Ccng2^−/− DN mice (original magnification, 200×). Values are presented as the mean ± SD (n = 3); < 0.05, < 0.01, n.s.: not significant.

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