Impact of Early versus Late Initiation of Renal Replacement Therapy in Patients with Cardiac Surgery-Associated Acute Kidney Injury: Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials
Table 5
Summary of findings table.
Early RRT versus Late RRT in patients with cardiac surgery-associated acute kidney injury
Patient or population: patients with cardiac surgery-associated acute kidney injury Settings: Intensive care medicine Intervention: Early RRT Comparison: Late RRT
Outcomes
Illustrative comparative risks (95 CI)
Relative effect(95 CI)
No of Participants(studies)
Quality of the evidence(GRADE)
Comments
Assumed risk
Corresponding risk
Late RRT
Early RRT
Mortality Follow-up: 14-30 days
Study population
RR 0.61 (0.33 to 1.12)
355(4 studies)
⊕⊝⊝⊝very low
426 per 1000
260 per 1000 (141 to 477)
Moderate
426 per 1000
260 per 1000 (141 to 477)
The basis for the assumed risk (e.g., the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). RRT=Renal replacement therapy, CI=Confidence interval, RR=Risk ratio.
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.
