Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI

Figure 8

HIF-1α signals changes in ISOM renal zones. HIF-1α was mainly localized in the renal ISOM, especially at 1 h. Marked nuclear accumulation of HIF-1α appears in the 1-day subgroup. Thereafter, staining gradually decreased over time, and they were detectable for 5 days. Asterisk indicates (compared with Group 1). Scale bar, 50 μm. (a) 1-day subgroup; (b) 3-day subgroup; (c) 5-day subgroup; (d) Group 1; (e) HIF-1α score.

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