Biological Aspect of Pathophysiology for Frozen Shoulder

Table 2

Results of matrix metalloproteinases in reviewed studies.

	Bunker et al. [14]	Brown et al. [19]	Kanbe et al. [16]	Kabbabe et al. [17]	A. M. T. Lubis and V. K. Lubis [18]
Sample size	14 FS & 5 DD & 4 normal subjects	9 DFS & 9 FS & 9 control subjects	10 FS subjects	13 FS & 10 control subjects	50 FS & 50 control subjects
Specimen	Capsule	RI	RI	Capsule	Serum
Method	RT-PCR	Luminex multiplex analysis	IHC	RT-PCR	ELISA
MMPs
MMP-1	(9/14)	↓		n.s.	↓
MMP-2	(13/14)	n.s.			↓
MMP-3	(5/14)	n.s.	(+++) (100%)	↑
MMP-7		(-)
MMP-8		n.s.
MMP-9	(8/14)	(-)
MMP-12		(-)
MMP-13		(-)		n.s.
MMP-14	(0/14)
TIMPs
TIMP-1	(14/14)	n.s.			↑
TIMP-2					↑
Others
ADAMTS 4				↑
ADAMTS 5				n.s.