Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis

Table 3

Pooled hazard ratios (HRs) for OS according to subgroup analyses.

Subgroup	No. of studies	No. of patients	HR (95% CI)	P value	Heterogeneity
					I^2(%)
Overall	8	1404	1.38 (1.19-1.62)	<0.001	16.5	0.30
Treatment
Surgery	5	840	1.43 (1.12-1.83)	0.005	30.8	0.22
Chemoradiotherapy	1	257	1.19 (0.91-1.55)	0.200	—	—
Mixed	1	120	1.89 (1.11-3.14)	0.020	—	—
Stage
Mixed	6	866	1.40 (1.18-1.67)	<0.001	8.2	0.36
Metastatic	1	257	1.19 (0.91-1.55)	0.200	—	—
Cut-off
≥150	3	485	1.59 (1.03-2.46)	0.036	56.2	0.102
<150	5	919	1.33 (1.14-1.56)	<0.001	0	0.505
Analysis method
Univariate	2	430	1.16 (0.93-1.45)	0.174	0	0.778
Multivariate	6	974	1.52 (1.27-1.81)	<0.001	0	0.426