Maxillary Bone Regeneration Based on Nanoreservoirs Functionalized ε-Polycaprolactone Biomembranes in a Mouse Model of Jaw Bone Lesion

Figure 6

Histological sections of the lesion at T0 (a) and after 30 days implantation of PCL (b, e), PCL/(BMP-2)₃ (c, f), and (PCL/(BMP-2)₃/(Ibu)₃) (d, g) scaffolds stained with hematoxylin-eosin. After 30 days the gingiva is healed and bone regenerates on both sides of the lesion with the 3 different scaffolds. When the membrane is functionalized with BMP-2 or BMP2/Ibu, we also observe bone regeneration inside the membrane (arrows in (f) and (g)). The osteoblasts migrate into the membrane. BL: bone lesion, G: gingiva, LBR: lesion with bone regeneration, NB: neoformed bone, and PCL: scaffold.

(a)

(b)

(c)

(d)

(e)

(f)

(g)