Evaluation of the Pharmacokinetics and Hepatoprotective Effects of Phillygenin in Mouse

Table 2

Pharmacokinetic parameters of phillygenin after single oral (24 mg/kg) or iv (12 mg/kg) to mice.

Parameter	po (24 mg/kg)	iv (12 mg/kg)
(μg·min/mL)	71.3	63.2
(μg·min/mL)	72.5	76.2
Vd (mL/kg)	^c NC	300
CL (mL/min/kg)	345	156
(g/mL)	^bNQ	3.14
(g/mL)	0.7	- -
(min)	30	- -
(min)	^c NC	3.78
(min)	^cNC	630
A Half-life (min)	54.8	- -
D Half–life (min)	150	^a NC
E Half-life (min)	240	^aNC
F ()	56.4	- -

^aNC = not calculated; low levels did not allow calculation of terminal half-life and .