Melatonin Modulation of Sirtuin-1 Attenuates Liver Injury in a Hypercholesterolemic Mouse Model

Figure 6

Schematic representation of melatonin effects against hypercholesterolemic hepatic alterations. It is important to underline that this indoleamine, together with its antioxidant properties, is able to reduce liver morphological alterations also blocking the decrease of sirtuin1 that in turn inhibits oxidative stress. The red symbols indicate the effect of melatonin in blocking the pathways induced by hypercholesterolemia that are indicated by the blue arrows. CAT: catalase; GSH: glutathione; iNOS: inducible nitric oxide synthase; SIRT1: sirtuin1; SOD1: superoxide dismutase1.