Bone Morphogenetic Proteins 2/4 Are Upregulated during the Early Development of Vascular Calcification in Chronic Kidney Disease

Figure 4

Aortic pathology was examined by gross observation, aortic von Kossa staining, and aortic Alizarin red staining. (a) Observation of gross aortic specimens revealed aortic aneurysm-like changes in the aorta in the chronic kidney disease (CKD) group; (b) aortic von Kossa staining showed gradually increased black granular deposition and formation of calcified nodules in the CKD group; (c) aortic Alizarin red staining showed progressively increased orange-colored granular deposition and formation of calcified nodules in the CKD group.

(a)

(b)

(c)