The Impact of Noncavity-Distorting Intramural Fibroids on the Efficacy of In Vitro Fertilization-Embryo Transfer: An Updated Meta-Analysis

Table 1

Characteristics of the studies included in this review (R: reproductive; P: perspective; IR: implantation rate; cPR: clinical pregnancy rate; LBR: live birth rate; MR: miscarriage rate; ePR: ectopic pregnancy rate).

Reference

Type

Study group

Control group

No. of; IVF cycles

Age; (year)

Size of fibroids; (mm)

No. of; fibroids

IR

cPR

LBR

MR

ePR

No. of; IVF cycles

Age

IR

cPR

LBR

MR

ePR

Eldar-Geva [6] 1998

R

55

35.3±1.2

23.7±7.1

1.82±0.35

6.4%

9/55

6/55

3/9

0/9

318

35.5±0.4

15.8%

98/318

78/318

16/98

4/98

Stovall [53] 1998

R

91

35.8±4.1

8-50

1.8±0.8

46/334

34/91

30/91

4/34

0/34

91

35.9±3.4

65/330

48/91

44/91

4/48

0/48

Rinehart [52] 1999

R

24

-

5-32.5

1-5

7/106

5/24

-

-

-

24

-

9/96

7/24

-

-

-

Dietterich [51] 2000

R

9

35+

6-26

1-6

10/30

5/9

5/9

0/5

0/5

11

35

12/37

7/11

6/11

1/7

0/7

Jun [50] 2001

R

141

36.9±4.0

19.3±12.6

-

-

43/141

34/141

8/43

1/43

406

34.8±4.2

-

169/406

142/406

22/169

5/169

Surrey [49] 2001

R

73

31-45

-

-

50/248

37/73

34/73

-

-

327

-

293/1037

191/327

173/327

-

-

Check [48] 2002

P

61

36.6±4.5

15±0.9

2.1±0.18

-

21/61

14/61

-

2/21

61

36.6±4.5

-

29/61

23/61

-

1/29

Yarali [47] 2002

R

73

35.9±3.3

30±18

3.1±2.0

18/183

16/73

-

1/16

-

324

35.6±3.9

102/911

90/324

-

6/90

-

Aboulgha [46] 2004

P

33

35.9±3.1

-

-

-

10/33

-

-

-

100

36.4±2.3

-

36/100

-

-

-

Oliveira [45] 2004

R

163

35.1±3.6

4-69

1-4

-

76/163

55/163

21/76

0/76

245

35.1±3.6

-

110/245

78/245

32/110

0/110

Wang [44] 2004

R

49

43±5.1

30.3

-

47/157

29/49

19/49

10/29

0/29

73

39.5±5.7

60/219

34/73

32/73

2/34

0/34

Ng [43] 2005

P

48

27-40

-3

1-6

13/96

11/48

-

2/11

0/11

47

27-4

9/94

7/47

4/47

3/7

0/7

Khalaf [42] 2006

P

112

36.4±3.9

23±11

1.8 ± 0.8

-

36/112

16/112

13/36

-

322

34.6±3.9

-

161/322

78/322

44/161

-

Manzo [41] 2006

R

65

37

20-50

-

-

13/65

6/65

6/13

-

366

37

-

85/366

50/366

25/85

-

Klatsky [40] 2007

R

69

42.7±0.5

28

-

-

22/69

-

-

-

275

40.9±0.28

-

149/275

-

-

-

Nejad [39] 2007

P

94

33.9±3.4

-

-

-

20/94

-

2/22

-

184

33.3 ±3.6

-

42/184

-

4/46

-

Vimercati [38] 2007

R

31

34.8±5.3

-

-

5/72

4/31

-

0/4

-

205

33.8±4.5

62/416

57/205

-

2/57

-

Horcajadas [37] 2008

R

807

-

-

-

-

429/807

-

94/429

-

135

-

-

80/135

-

12/80

-

Bozdag [36] 2009

R

61

35.3±4.5

-

-

33/162

22/61

-

6/22

-

444

34.5 ± 3.6

250/1299

167/444

-

31/167

-

Somigliana [35] 2011

P

119

37.6±3.0

22.0±10.0

1-5

-

28/119

22/119

-

-

119

37.6±3.0

-

22/119

16/119

-

-

Guven [34] 2013

R

62

33.0±4.0

49.6±12.3

1

-

16/62

11/62

2/16

-

301

32.66±5.3

-

120/301

93/301

11/120

-

Yan [31] 2014

R

249

35.0±4.0

60

-

149/514

120/249

84/249

36/120

-

249

35.0±4.0

139/507

110/249

76/249

34/110

-

Li [33] 2014

R

200

-

-

-

69/481

52/200

38/200

14/52

-

200

-

84/472

68/200

55/200

13/68

-

Liu [32] 2014

R

104

34.1±3.9

24.2±13.7

-

687/763

46/104

36/104

8/46

2/46

312

30.7± 4.2

1685/2680

147/312

125/312

20/147

2/147

Lu [30] 2015

P

117

33.0

40

-

75/235

54/117

39/117

11/54

-

117

33.0

95/208

68/117

61/117

5/68

-

Christopoulos [29] 2016

R

163

35.7±3.6

25

1-8

-

53/163

44/163

-

-

326

35.7±3.6

-

139/326

125/326

-

-

Long [28] 2016

R

167

35.9± 3.5

-

-

122 /397

83 /167

62/167

17 /83

2 /83

167

35.9±3.5

123 /384

85 /167

71/167

10 /85

1/85

Dai [27] 2017

R

100

36.4±3.9

-

-

59 /221

48 /100

32/100

10 /48

-

100

36.2 ± 4.3

67 /220

51 /100

28/100

16 /51

-