Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients

Figure 2

Perfused boundary region changes based on fluid challenge response. Legend: Panel (a) PBR changes in surgical patients (Cohort OR); Panel (b) PBR changes in patients with sepsis/septic shock (Cohort SEP). Abbreviations: Responder FR (white): patients with positive hemodynamic response to fluid challenge; NON-Responder NR (grey): patients with negative hemodynamic response to fluid challenge; PBR: perfused boundary region; TP 0, 1, 20, 40, 60, 120: measurement point immediately before, immediately after, and at 20, 40, 60, and 120 minutes after fluid challenge; : significant difference between responders and non-reposnders.

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