Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients
Table 1
Baseline characteristics.
Group F
Group S
All
Cohort OR
Cohort SEP
All
Cohort OR
Cohort SEP
(N=32)
(N=25)
(N=7)
(N=34)
(N=25)
(N=9)
Age (years)
60.1 ± 14.7
59.5 ± 12.9
61.1 ± 18.1
60 ± 16.6
61.7 ± 15.2
56.7 ± 19.3
Sex (Female/male)
18/14
14/11
4/3
18/16
15/10
3/6
Height (cm)
167.8 ± 12.5
169.3 ± 11.2
165 ± 26
167.3 ± 11.1
168 ± 8.8
165.9 ± 26.1
Weight (kg)
88.8 ± 26.3
85.6 ± 17.3
95.7 ± 39.3
87.2 ± 26.2
82.9 ± 15.1
95.8 ± 39.8
Predicted body weight (kg)
64.0 ± 11.1
64.0 ± 11.3
64.2 ± 11.5
64.0 ± 9.8
62.3 ± 8.9
65.9 ± 11.2
Fluid challenge infusion rate (ml/min)
46 (39-54)
44 (39-54)
47 (40-52)
11 (9-12)
10 (9-12)
11 (10-13)
Chronic conditions
ASA grade (1/2/3)
-
5/9/11
-
-
5/13/6
-
APACHE II score
-
-
26.6 ± 7.2
-
-
27.2 ± 9.6
SOFA score
-
-
10 (7.3 – 14.3)
-
-
8 (7.8 – 12.3)
Hypertension (no.)
21
15
3
17
12
4
Smoking (no.)
10
6
3
9
4
2
Diabetes (no.)
10
9
1
6
5
1
Operative procedure
Laminectomy
-
9
-
-
6
-
Discectomy
-
5
-
-
14
-
Fixation
-
11
-
-
5
-
Intraoperative blood loss (ml)
-
175
-
-
300
-
(100 – 300)
(188-400)
Sepsis origin and nature
Lungs
-
-
2
-
-
5
Abdomen
-
-
5
-
-
2
Bloodstream
-
-
0
-
-
1
Orofacial
-
-
0
-
-
1
Vasopressor use (no (%))
-
-
6 (86%)
-
-
8 (89%)
Noradrenalin dose (μg/kg/min)
-
-
0.46
-
-
0.38
(0.13-0.50)
(0.24-0.71)
Septic shock
-
-
4 (57%)
-
-
8 (89%)
Baseline biochemistry
Hematocrit (%)
39.6 ± 6.3
42.6 ± 3.3
33.6 ± 6.6
39.8 ± 5.9
42.5 ± 3.4
34.2 ± 6.2
Sodium (mmol/l)
140.9 ± 3.6
140.7 ± 2.7
141 ± 5.0
140.7 ± 4.2
140.4 ± 2.9
141.3 ± 6.3
Protein (g/l)
63.7 ± 9.8
68.4 ± 7.4
55.6 ± 19.3
66.3 ± 9.7
71.4 ± 11.3
55.6 ± 8.2
Creatinine (umol/l)
103.6 ± 67.4
75 ± 19.2
160.7 ± 91.4
95.5 ± 59.5
71.9 ± 4.1
145.7 ± 85.2
C-reactive protein (mg/l)
-
-
266.6 ± 30.0
-
-
265.2 ± 29.9
Procalcitonin (ug/l)
-
-
16.0 ± 8.5
-
-
16.1 ± 8.5
Serum lactate (mmol/l)
-
-
2.18 ± 1.27
-
-
2.66 ± 0.73
Data are displayed as mean ± standard deviation, median (25th-75th percentile), or number (proportion). Abbreviations: APACHE II: Acute Physiology and Chronic Health Evaluation score-second version; ASA: American Society of Anesthesiology physiological status; SOFA: Sequential Organ Failure Assessment.
