Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients
Table 4
Macrohemodynamic changes induced by fluid challenge in the whole population.
Variable
Time-point
Group F
Group S
P value (between groups)
(N=32)
(N=34)
MAP (mmHg)
T0
77 ± 11
78 ± 11
0.800
T1
85 ± 13
78 ± 12
0.024
T60
85 ± 11
85 ± 12
0.986
p value
0.027
0.025
Pulse pressure (mmHg)
T0
37 (30-43)
35 (30-55)
0.893
T1
40 (35-45)
39 (30-51)
0.338
T60
38 (31-48)
40 (31-61)
0.496
p value
0.205
0.017
Heart rate (per minute)
T0
69 (60-79)
70 (63-81)
0.603
T1
64 (59-75)
68 (58-82)
0.812
T60
68 (63-87)
74 (65-88)
0.481
0.174
0.209
Plethysmography Variability index (%) (OR cohort)
T0
13 (7-20)
15 (12-21)
0.281
T1
10 (7-11)
10 (7-14)
0.276
T60
13 (8-17)
11 (10-15)
0.879
p value
0.086
0.087
Stroke volume variation (%) (SEP cohort)
T0
12 (10-19)
5 (2-9)
0.016
T1
6 (6-11)
6 (4-10)
0.568
T60
4 (4-14)
7 (3-12)
0.936
p value
0.621
0.013
Stroke volume index (ml/m2) (SEP cohort)
T0
33 ± 14
40 ± 20
0.515
T1
32 ± 14
44 ± 20
0.320
T60
33 ± 13
44 ± 16
0.281
p value
0.750
0.563
Values are displayed as either median (interquartile range) or mean ± standard deviation; : significant difference towards baseline (RM ANOVA or Friedman test), significance marked in bold letters. Abbreviations: Group F: fast administration; Group S: slow administration; MAP: mean arterial pressure; PVI: plethysmography variability index; SVV: stroke volume variation; PBR: perfused boundary region; SEP cohort: patients with sepsis/septic shock.
