Investigation of MicroRNA in Mitochondrial Apoptotic Pathway in Systemic Lupus Erythematosus

Table 2

Correlation analysis between microRNA and leukocyte viral infection/activation markers.

	SLEDAI	casp-9 (37 kD)	casp-10 (59 kD)	MDA5	MAVS (70 kD)	MAVS (57 kD)	CRP
miR-22-3p; ΔCT
	−.12	−.08	−.47	.08	.10	−.38	−.09
	.63	.75	<.05	.77	.69	.13	.65
miR-150-5p; ΔCT
	.70	−.03	−.13	−.36	−.49	−.06	.56
	.00	.91	.60	.15	.04	.81	<.01
miR-221-3p; ΔCT
	−.12	−.12	−.02	.13	.21	−.39	.09
	.65	.64	.93	.61	.40	.11	.65
miR-21-5p; ΔCT
	.02	−.23	−.62	.01	−.07	−.21	.23
	.92	.35	.01	.98	.78	.40	.21

Method: Spearman’s rho for nonlinear distributed variables or Pearson correlation for linear distributed variables; , correlation coefficient; , value; , number; casp, caspase; SLEDAI-2K, systemic lupus erythematosus disease activity index 2000; ΔCT, compared with miR-541a as control (CT); pIRF7, phosphorylated interferon regulator factor 7; MAVS, mitochondrial antiviral signaling protein; MDA5, melanoma differentiation-associated protein 5; CRP, c-reactive protein (mg/dL); , correlation is significant at the 0.05 level.