The Toxic Effects of Aflatoxin B1 and Aflatoxin M1 on Kidney through Regulating L-Proline and Downstream Apoptosis

Figure 8

TOC Graphic. With the 28-day administration of AFB1, AFM1, and AFB1+AFM1, mice serum biochemical indicators changed significantly; mice kidney tissue showed injury with different degrees, when compared with the control, indicating AFB1, AFM1, and AFB1+AFM1 caused kidney damage and activated oxidative reaction. Through metabonomics detection of kidney tissue, L-proline was verified to be the key metabolite in kidney tissue in response to these aflatoxins. Then in mechanism exploration part, PRODH was validated to be the upstream regulator of L-proline, which also induced downstream apoptosis.