Research Article
Integration of Gene Expression Profile Data to Screen and Verify Hub Genes Involved in Osteoarthritis
Table 2
The significant enriched analysis of DEGs in osteoarthritis.
| | Expression | Category | Term | Description | Gene Count | P-Value |
| | DOWN-DEGs | BP | GO:0006911 | phagocytosis, engulfment | 5 | 3.11E-05 | | BP | GO:0045087 | innate immune response | 9 | 0.001731552 | | BP | GO:0043406 | positive regulation of MAP kinase activity | 4 | 0.003542436 | | BP | GO:0006508 | proteolysis | 9 | 0.004361459 | | BP | GO:0006956 | complement activation | 4 | 0.010412249 | | CC | GO:0005615 | extracellular space | 24 | 8.12E-08 | | CC | GO:0005576 | extracellular region | 23 | 6.94E-06 | | CC | GO:0042571 | immunoglobulin complex, circulating | 3 | 0.003820636 | | CC | GO:0005886 | plasma membrane | 32 | 0.005732121 | | CC | GO:0000139 | Golgi membrane | 9 | 0.008249883 | | MF | GO:0004252 | serine-type endopeptidase activity | 7 | 0.001703259 | | MF | GO:0008144 | drug binding | 4 | 0.006434471 | | MF | GO:0034987 | immunoglobulin receptor binding | 3 | 0.007358675 | | MF | GO:0008201 | heparin binding | 5 | 0.008337436 | | MF | GO:0008083 | growth factor activity | 5 | 0.008701217 |
| | UP-DEGs | BP | GO:0044344 | cellular response to fibroblast growth factor stimulus | 7 | 2.20E-07 | | BP | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 27 | 4.77E-07 | | BP | GO:0051591 | response to cAMP | 7 | 3.08E-06 | | BP | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 21 | 5.86E-06 | | BP | GO:0043066 | negative regulation of apoptotic process | 16 | 1.31E-05 | | CC | GO:0005634 | nucleus | 75 | 6.25E-07 | | CC | GO:0005654 | nucleoplasm | 47 | 2.11E-06 | | CC | GO:0005737 | cytoplasm | 61 | 0.002569078 | | CC | GO:0005829 | cytosol | 43 | 0.002630227 | | CC | GO:0005667 | transcription factor complex | 6 | 0.02296627 | | MF | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 12 | 1.03E-05 | | MF | GO:0005515 | protein binding | 106 | 2.10E-05 | | MF | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 5 | 5.02E-05 | | MF | GO:0044822 | poly(A) RNA binding | 25 | 7.91E-05 | | MF | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | 4 | 1.95E-04 |
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