Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells

Figure 1

The vasorelaxation effect of Tsantan Sumtang on intact endothelium pulmonary arterial rings and the effects of L-NAME and IMT on Tsantan Sumtang induced rat pulmonary artery vasorelaxation (n=6). Ctr: control group administered with Tsantan Sumtang but without any inhibitors. SW: Tsantan Sumtang. Tsantan Sumtang dilated the vessels gradually from 0.3 to 0.9 mg/mL and roared to the max relaxation at 1.2 mg/mL. To test the mechanisms involved in the vasorelaxation effect of Tsantan Sumtang, different inhibitors were used. The rings were constricted furthest with 1 μmol/L of NE, and then L-NAME (eNOS inhibitor, 100 μmol/L) and IMT (cyclooxygenase inhibitor, 10 μmol/L) were administered. After reaching a new stable phase, Tsantan Sumtang was added in an accumulative way (from 0.3 to 1.2 mg/mL). The dosage reactions with or without the inhibitors were shown as (a) and column (b) giving a more visual image for the max relaxation rates (^ΔP<0.05 compared to control group, <0.05 compared to L-NAME).

(a)

(b)