Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells

Figure 2

The influences of K⁺ channels inhibitors on Tsantan Sumtang-induced rat pulmonary artery vasorelaxation (n=6). Ctr: control group administered with Tsantan Sumtang but without the inhibitors. SW: Tsantan Sumtang. TEA (large-conductance Ca²⁺-activated K⁺ channel inhibitor, 1 mmol/L), BaCl₂ (inward rectifier K⁺ channel inhibitor,1 mmol/L), and 4-AP (voltage-dependent K⁺ channel inhibitor, 1 mmol/L) were used to test the mechanisms involved in Tsantan Sumtang-induced rat pulmonary artery vasorelaxation too. The dosage reactions with or without the inhibitors were shown as (a) and column (b) giving a more visual image for the max relaxation rates. The vasorelaxation effect of Tsantan Sumtang was markedly blocked by all three K⁺ channel inhibitors, with a max reduction to 64.5%  ± 0.38%, 24.56%  ± 0.38%, and 40.87%  ± 0.40%, respectively (^ΔP<0.05 compared to control group). Among them, BaCl₂ and TEA expressed stronger blocking effect than 4-AP (<0.05 compared to 4-AP) and BaCl₂ is the strongest blocker (^◆P<0.05 compared to TEA).

(a)

(b)