Tsantan Sumtang Alleviates Chronic Hypoxia-Induced Pulmonary Hypertension by Inhibiting Proliferation of Pulmonary Vascular Cells

Figure 7

Effects of Tsantan Sumtang on p27Kip1 protein expression in lung tissue of HPH rats (n=5). Ctr: control group; Hyp: untreated hypoxia group (rats exposed to hypoxia in hypobaric chamber, equal to the parameter in altitude 4500 m), and Hyp+SW-treated groups (rats exposed to hypoxia in hypobaric chamber and received increasing doses of Tsantan Sumtang treatment, 1.0 g/kg, 1.25 g/kg, and 1.5 g/kg). Upper panel: relative expression levels of p27Kip1 protein (optical density of p27Kip1 normalized against β-actin expression). Lower panel: β-actin protein expression was used as control. p27Kip1 expression was notably decreased in Hyp group and low dose of Tsantan Sumtang treatment rats, but the 1.25 g/kg and 1.5 g/kg of Tsantan Sumtang administration significantly elevated p27Kip1 protein expression and had no difference with the control rats (^ΔP< 0.05 compared to Hyp; < 0.05 compared to Ctr).