miR-30 Family: A Promising Regulator in Development and Disease

Table 2

The targets of miR-30 family members in tissue and organ development and clinical diseases.

	Types	miRNAs	Targets	Cells/Models	References
Tissue and organ development	Bone tissue	miR-30a, miR-30d; miR-30a, miR-30b, miR-30c, miR-30d; miR-30a,	BMP2; Smad1, Runx2; Runx2	C2C12 cells; MC3T3-E1 cells; C3H10T1/2 cells	[7]; [8]; [9]
	Reproductive system	miR-30 family	Skp2, Ubej1	CHO cells	[10]
	Adipose tissue	miR-30a, miR-30d	Runx2	hMADS cells	[11]
		miR-30b, miR-30c	UCP1, Cidea, RIP140	C57BJ6 mice	[12]
	Vessel	miR-30b, miR-30c	DLL4	LECs, HUVECs	[13]
Related diseases	Tumorigenesis  (as tumor suppressor)	miR-30a	Beclin1	Daoy, D283, D425 cells	[14]
		miR-30d	ATG5, PI3K, Beclin1	HCT15, HCT116, HT-29, DLD-1, SW480 cells	[15]
	Tumorigenesis (as oncogene)	miR-30a	FOXL2, BCLA1,; IER3, cyclin D2	COV434 cells	[16]
		miR-30b, miR-30d	GALNT7	Melanoma cells, clinical specimens	[17]
	Cardiovascular disease	miR-30e	ACE2	Sprague Dawley rats	[18]
		miR-30	ATG6	ApoE^(-/-) mice, HAECs	[19]
		miR-30a	DLL4	Zebrafish	[20]
	Renal disease	miR-30 family	Notch1, p53	Wistar rats, human podocytes, clinical specimens	[21]
		miR-30d	TGF-β	HEK293 cells	[22]
	Osteoarthritis	miR-30b	ERG	SW1353 cells, clinical specimens	[23]
	Hepatic fibrosis	miR-30	TGF-β	ICR mice, HSCs	[24]
	Pulmonary fibrosis	miR-30a	WISP1	Sprague Dawley rats, primary human lung fibroblasts	[25]
	Tuberculosis	miR-30a	MyD88	THP-1 cells	[26]
	Radiation damage	miR-30c	REDD1	hFOB cells, CD34^+ cells	[27]
		miR-30b, miR-30c	NF-κB	CD2F1 mice, CD34^+ cells	[28]
		miR-30b, miR-30c	Mcl-1	CD2F1 mice, CD34^+ cells	[29]

 Notes. BMP2: bone morphogenetic protein-2; Smad1: SMAD family member 1; Runx2: runt-related transcription factor 2; Skp2: S-phase kinase related protein 2; Ubej1: ubiquitin-conjugating enzyme E2, J1; UCP1: uncoupling protein 1; Cidea: cell death-inducing DFFA-like effector a; DLL4: δ-like ligand 4; ATG5: autophagy related protein 5; PI3K: phosphoinositide 3-kinase; FOXL2: forkhead box protein L2; BCLA1: B-cell lymphoma 2 related protein A1; IER3: immediate early response 3; IL-10: interleukin-10; ACE2: angiotensin-converting enzyme 2; ATG6: autophagy related protein 6; TGF-β: transforming growth factor-β; ERG: EST-related genes; WISP1: WNT1-induced signaling pathway protein 1; MyD88: bone marrow differentiation factor 88; REDD1: DNA damage inducible transcript 4; NF-KB: nuclear factor kappa B; Mcl-1: BCL2 family apoptosis regulator.