Research Article
Cross-Protective Efficacy of Monovalent Live Influenza B Vaccines against Genetically Different Lineages of B/Victoria and B/Yamagata in Ferrets
Table 2
Clinical observations in ferrets after challenge with B/Brisbane/60/2008 (B/Vic) or B/Phuket/3073/2013 (B/Yam) wild-type influenza virus.
| | After challenge with B/Vic WT virus | Body temperature (°C) | Activity (group average) | Respiratory symptoms (group average) | | Day 21 | Day 22 | Day 23 | Day 24 | Day 21 | Day 22 | Day 23 | Day 24 | Day 21 | Day 22 | Day 23 | Day 24 |
| | B/Vic LAIV (group 1) | 38.7 | 38.4 | 38.8 | 38.5 | 3.0 | 2.0 | 2.3 | 2.7 | 0.0 | 0.0 | 0.0 | 0.0 | | B/Yam LAIV (group 4) | 38.8 | 38.4 | 38.5 | 38.2 | 3.0 | 2.3 | 2.3 | 2.3 | 0.0 | 0.7 | 1.01 | 0.3 | | Unvaccinated control (group 5) | 38.9 | 39.2 | 39.0 | 38.5 | 3.0 | 1.01 | 1.71 | 2.3 | 0.0 | 0.7 | 0.7 | 0.3 | | Intact animals (group 7) | 38.5 | 38.4 | 38.8 | 38.4 | 3.0 | 3.0 | 3.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| | After challenge with B/Yam WT virus | Body temperature (°C) | Activity (group average) | Respiratory symptoms (group average) | | Day 21 | Day 22 | Day 23 | Day 24 | Day 21 | Day 22 | Day 23 | Day 24 | Day 21 | Day 22 | Day 23 | Day 24 |
| | B/Yam LAIV (group 3) | 38.7 | 38.6 | 39.0 | 38.6 | 3.0 | 2.3 | 2.3 | 3.02 | 0.0 | 0.7 | 0.7 | 0.0 | | B/Vic LAIV (group 2) | 38.7 | 38.3 | 38.2 | 38.7 | 3.0 | 1.71 | 1.71 | 2.3 | 0.0 | 0.7 | 0.3 | 0.0 | | Unvaccinated control (group 6) | 38.8 | 39.1 | 39.2 | 38.8 | 3.0 | 1.31 | 1.71 | 2.01 | 0.0 | 1.01 | 1.01 | 0.7 | | Intact animals (group 7) | 38.5 | 38.4 | 38.8 | 38.4 | 3.0 | 3.0 | 3.0 | 3.0 | 0.0 | 0.0 | 0.0 | 0.0 |
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Statistically significant differences: 1Dunnett test, p≤0.05 (versus intact group); 2Dunnett test, p≤0.05 (vaccinated animals versus unvaccinated control).
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