The Chinese Medicinal Formulation Guzhi Zengsheng Zhitongwan Modulates Chondrocyte Structure, Dynamics, and Metabolism by Controlling Multiple Functional Proteins

Table 9

Differentially expressed proteins that were classified into other eggNOG categories (GZZSZTW versus Blank).

Protein name	Fold change	Q value
Transcription
Death-associated protein 1 (Dap)	3.140	0.001
Protein S100-A1 (S100a1)	2.538	0.009
Methyl-CpG-binding protein 2 (Mecp2)	2.056	0.040
High mobility group protein HMG-I/HMG-Y (Hmga1)	1.959	0.001
Prothymosin alpha (Ptma)	1.890	0.016
Nuclear factor 1 A-type (Nfia)	1.787	0.028
Tudor domain-containing protein 1 (Tdrd1)	0.619	0.001
Lactotransferrin (Ltf)	0.550	0.003
Extracellular structures
Granulocyte colony-stimulating factor receptor (Csf3r)	8.552	0.001
Collagen alpha-1(X) chain (Col10a1)	2.161	0.001
Matrix Gla protein (Mgp)	1.535	0.003
Alpha-fetoprotein (Afp)	0.637	0.001
Lactotransferrin (Ltf)	0.550	0.003
Serum albumin (Alb)	0.545	0.001
Alpha-2-HS-glycoprotein (Ahsg)	0.364	0.001
Intracellular trafficking, secretion, and vesicular transport
Granulocyte colony-stimulating factor receptor (Csf3r)	8.552	0.001
Sorting nexin-3 (Snx3)	1.865	0.027
Ran-specific GTPase-activating protein (Ranbp1)	1.641	0.001
Mitochondrial fission factor (Mff)	1.503	0.010
Disabled homolog 2 (Dab2)	1.500	0.001
RNA processing and modification
Prothymosin alpha (Ptma)	1.890	0.016
Serine/arginine-rich splicing factor 5 (Srsf5)	1.526	0.001
Amino acid transport and metabolism
Chymotrypsinogen B (Ctrb1)	0.511	0.001
Kallikrein 1-related peptidase b1 (Klk1b1)	0.291	0.019
Inorganic ion transport and metabolism
Lactotransferrin (Ltf)	0.550	0.003
Zinc transporter ZIP8 (Slc39a8)	0.395	0.001
Carbohydrate transport and metabolism
Glyceraldehyde-3-phosphate dehydrogenase (Gapdh)	1.547	0.001
Replication, recombination and repair
Prothymosin alpha (Ptma)	1.890	0.016
Cell cycle control, cell division, chromosome partitioning
Septin-7 (Sept7)	1.623	0.001
Energy production and conversion
Prothymosin alpha (Ptma)	1.890	0.016