Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease

Table 1

Main characteristics of the total group and different psoriatic disease groups.

	Total PD, N = 690	No PsA, N = 503	PsA, N = 187	PCP, N = 309	value
Onset age (mean, years)	27	27	28	21
Early onset	176 (26%)	135 (27%)	41 (22%)	36 (12%)	0.002
PASI >10	371 (54%)	249 (50%)	122 (65%)	190 (61%)	0.40
Male sex	381 (55%)	292 (58%)	89 (48%)	182 (59%)	0.01
Cw6 positive	304 (44%)	234 (47%)	70 (37%)	166 (54%)	<0.001
NFKB1 rs230526 A	42%	42%	41%	40%	0.76
NFKBIA rs7152376 T	35%	33%	42%	31%	<0.001
NFKBIZ rs3217713 ins	20%	19%	20%	17%	0.23

values correspond to the PsA vs. PCP groups. For the three NFKB polymorphisms, we show the minor allele frequencies. PD: psoriatic disease; PsA: psoriatic arthritis; PCP: pure cutaneous psoriasis (absence of arthritis after 10 or more years of psoriasis onset).