Integrative Network Analysis Reveals a MicroRNA-Based Signature for Prognosis Prediction of Epithelial Ovarian Cancer

Table 2

Univariate and multivariate analysis.

	Validation Cohort (GSE73582)				Validation Cohort (GSE25204)
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)		HR (95% CI)		HR (95% CI)		HR (95% CI)
Age (<65 vs. >=65)	1.51 (0.94-2.43)	0.08	1.33 (0.82-2.16)	0.24	0.88 (0.54-1.42)	0.6	0.86 (0.53-1.41)	0.55
Grade (3 vs. 1&2)	1.42 (0.92-2.18)	0.11	1.21 (0.78-1.87)	0.39	0.89 (0.58-1.38)	0.62	0.90 (0.58-1.40)	0.65
Stage (III&IV vs. I&II)	2.57 (1.44-4.61)	0.001	2.57 (1.39-4.73)	0.002
Debulking (optimal vs. suboptimal)	2.17 (1.37-3.44)	0.001	1.81 (1.12-2.91)	0.01	2.19 (1.45-3.32)	0.0001	1.80 (1.17-2.77)	0.007
miRNA predictor (high vs low risk)	2.04 (1.34-3.10)	0.0008	1.82 (1.17-2.81)	0.007	2.59 (1.72-3.88)	4.46E-06	2.23 (1.46-3.41)	0.0002