Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells

Figure 1

The effect of matrine in the nontoxic concentration on apoptosis and rhodamine 123 accumulation in K562 and K562/ADR cells. (a) Chemical structure of matrine. (b) Evaluation of the nontoxic concentration of matrine carried out by WST-8 assay. (c) and (d) Enhancement of DOX-induced apoptosis by matrine, measured by Annexin V-FITC and DRAQ 7 staining with flow cytometry. (e), (f), (g), and (h) Change in intracellular rhodamine 123 (Rho 123) accumulation by matrine, examined by flow cytometry. All the data were expressed as mean and SD of three independent experiments ((b), (c), (f), and (h); , , ; ANOVA or t-test).

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