Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells

Figure 2

Effects of matrine on drug exporters and activation of NF-kappa B. (a) ABCB1, ABCC1, and ABCG2 mRNA expressions measured by quantitative real-time PCR analysis, 2-△△Ct assay. (b) and (c) ABCB1 protein expressions examined by western blotting. (d), (e), and (f) NF-kappa B and p-NF-kappa B protein expressions examined by western blotting. All the data were expressed as mean and SD of three independent experiments ((a), (b), and (f); , ; ANOVA).

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