The State of Exosomes Research: A Global Visualized Analysis

Table 1

The characteristic of exosomes comparing with microvesicle and apoptotic body.

Characteristic	Size	Morphology	Protein Marker	Origin	Mechanism of discharge	Composition
Exosomes	50-120nm	Cup-shaped	Alix, Tsg101, CD63, CD9	Multivesicular Body	Exocytosis of MVBs	Protein, miRNA, mRNA
Microvesicle	100-1000nm	Heterogeneous	Selectins, integrins, CD40	Plasma Membrane	Budding from plasma membrane	Protein, miRNA, mRNA
Apoptotic Body	50-500nm	Heterogeneous	Histones	Programmed cell death	Cell shrinkage and death	Protein, DNA, miRNA, mRNA