miR-451 Silencing Inhibited Doxorubicin Exposure-Induced Cardiotoxicity in Mice

Figure 5

miR-451 inhibition attenuated oxidative stress and apoptosis in H9c2 cells. (a) The level of miR-451 expression after a miR-451 inhibitor treatment (n=6). (b) The level of ROS in H9c2 cells (n=6). (c) The level of 4-HNE in H9c2 cells (n=6). (d) The MDA content in H9c2 cells (n=6). (e) Cell viability after Dox treatment (n=6). (f) The activity of caspase3 in H9c2 cells (n=6). P<0.05 compared with the group with PBS. ^#P<0.05 compared with Dox-treated H9c2 cells.

(a)

(b)

(c)

(d)

(e)

(f)