A Combination of an Antimitotic and a Bromodomain 4 Inhibitor Synergistically Inhibits the Metastatic MDA-MB-231 Breast Cancer Cell Line

Figure 3

MDA-MB-231 (a and c) and MCF-7 (b and d) cell numbers expressed as a % of cells relative to the negative control (vehicle: DMSO) after being exposed to ITH-47 (6.25–150 μM) (a and b) and ESE-15-ol (c and d) for 48 hours. ITH-47 inhibited the growth of MDA-MB-231 (a) and MCF-7 (b) cells by 50% (48 hours) at concentrations of 15 μM (a) and 75 μM (b). ESE-15-ol inhibited the growth of MDA-MB-231 (c) and MCF-7 (d) by 50% (48 hours) at concentrations of 70 nM (c) and 60 nM (d). indicates value <0.05, while indicates value <0.01 versus control.

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