A Combination of an Antimitotic and a Bromodomain 4 Inhibitor Synergistically Inhibits the Metastatic MDA-MB-231 Breast Cancer Cell Line

Figure 4

Distribution of DNA content relative to phases of the cell cycle of MDA-MB-231 cells (a) and MCF-7 cells (b). Significantly more MDA-MB-231 cells were observed in the G₁ phase when treated with ITH-47 compared to the DMSO control and significantly more cells in the sub-G₁ phase when treated with the ITH-47 + ESE-15-ol compared to the DMSO control following 48 hours of exposure (a). Significantly more MCF-7 cells in the G₁ phase were observed when treated with ITH-47-treated and ITH-47 + ESE-15-ol compared to the DMSO control (b). indicates value <0.01.

(a)

(b)