A Combination of an Antimitotic and a Bromodomain 4 Inhibitor Synergistically Inhibits the Metastatic MDA-MB-231 Breast Cancer Cell Line

Table 1

Combination index (CI) and GI₅₀ values at 48 hours for ITH-47 and ESE-15-ol combinations.

Cell line	ITH-47 (GI50)	ESE-15-ol(GI50)	Combination index	Combination GI50	Interpretation
MDA-MB-231	15 μM	70 nM	0.7	ITH-47: 7.5 μM; ESE-15-ol: 14 nM	Synergism

CI < 1 indicates synergistic effect, CI = 1 indicates additive effects, and CI > 1 indicates antagonistic effect.