The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats

Table 1

Pharmacokinetic parameters of SRL after the administration of TRQ at different doses.

Parameter	Control Group	Group A1	Group A2	Group A3
Tmax (h)	4.167±2.563	6.500±2.811	5.167±3.251	6.333±2.658
Cmax (ng/mL)	9.487±1.479	15.546±4.234	12.201±1.153	16.043±1.437
(h)	68.144±63.013	57.543±46.635	47.119±43.595	118.158±186.146
(ng·h/mL)	219.673±32.306	349.346±69.514	305.875±31.417	421.518±42.166
(ng·h/mL)	493.458±271.184	684.035±233.463	588.668±339.317	1456.282±1708.762
(ng·h/mL)	4122.178±593.331	6577.191±1205.275	5935.337±819.676	8394.303±820.509
(h)	18.772±0.456	18.881±0.946	19.343±0.976	19.919±0.275

P<0.01, compared with control group.