The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats

Table 2

Pharmacokinetic parameters of SRL after the administration of TRQ at different time.

Parameter	Control Group	Group B1	Group B2	Group B3
Tmax (h)	4.167±2.563	5.167±3.251	5.001±4.472	3.001±2.449
Cmax (ng/mL)	9.487±1.479	12.201±1.153	11.643±3.648	12.699±3.479
(h)	68.144±63.013	47.119±43.595	65.408±27.871	33.299±14.359
(ng·h/mL)	219.673±32.306	305.875±31.417	301.677±73.315	296.211±65.286
(ng·h/mL)	493.458±271.184	588.668±339.317	694.003±91.568	456.371±133.544
(ng·h^2/mL)	4122.178±593.331	5935.337±819.676	6157.161±1329.936	5635.173±1350.868
(h)	18.772±0.456	19.343±0.976	20.527±0.801	18.962±0.716

P<0.01, compared with control group.