Research Article
Extract from Bougainvillea xbuttiana (Variety Orange) Inhibits Production of LPS-Induced Inflammatory Mediators in Macrophages and Exerts a Protective Effect In Vivo
Figure 1
Effect of BxbO extract on LPS-induced inflammatory cytokine expression in mouse. Macrophages were treated with LPS (10 μg/100 μL), BxbO 1 hour after LPS challenge, or BxbO 1 before LPS challenge or BxbO plus LPS for 12, 24, 36, and 48 hours. After the indicated time the supernatants were collected, and the levels of mediators were determined as described in Methods. Each bar represents the mean values from 3 different experiments. Statistical significance in comparison with the LPS group is registered, p < 0.01; p < 0.001.