Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics

Table 1

The main characteristics of included 10 studies.

Study	Year	Region	Study design	Disease	N	Stage	Sample	miRNA-15a	Cut-off	Survival analysis	Follow-up Time(month)
								assay
Utaijaratrasmi	2018	Thailand	R	ICC	72	I-III	Tissue	qRT-PCR	NR	RE	Median 36
Gopalan et al	2018	Australia	R	CRC	124	II-IV	Tissue	qRT-PCR		SC	Median 78
Fesler et al	2018	US	R	CRC	431	II-IV	Tissue	qRT-PCR	0.65	SC	Up to 120
Shi et al	2017	China	R	OSM	127	I-III	Tissue	qRT-PCR		SC	Median 47.5
Kontos et al	2017	Greece	R	CRC	182	I-IV	Tissue	qRT-PCR	0.54	RE	Median 33
Li.J et al	2016	China	R	ESCC	106	I-III	Serum	qRT-PCR		RE	Median 28
Xie et al	2015	China	R	Glioma	128	I-IV	Tissue	qRT-PCR	Median	RE	Median 42.8
Shinden et al	2015	Japan	R	BC	230	I-IV	Tissue	qRT-PCR	NR	RE	Up to 60
Li.F et al	2015	China	R	MM	90	NR	Bone marrow	qRT-PCR	Median	RE	Median 15
Xiao et al	2014	China	R	CRC	126	I-IV	Tissue	qRT-PCR	Median	RE	Median 74

R, retrospective; BC, breast cancer; ICC, cholangiocarcinoma; CRC, colorectal cancer; OSM, osteosarcoma; ESCC, esophageal squamous cell carcinoma; MM, multiple myeloma; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; RE, reported; SC: survival curve; NR, not reported.