Less Vertebral Bone Mass after Treatment with Macitentan in Mice: A Pilot Study

<div><i>ALP, OCN, and TRAP expression in the 5</i><sup><i>th</i></sup><i> lumbar vertebral spongiosa</i> Immunohistochemistry demonstrated fewer ALP(+) and OCN(+) cells (brown) but more TRAP(+) (red) cells in Treatment group compared to Control group (ALP: alkaline phosphatase, OCN: Osteocalcin, and TRAP: tartrate-resistant acid phosphatase).</div>

BioMed Research International

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Figure 3: Less Vertebral Bone Mass after Treatment with Macitentan in Mice: A Pilot Study 