YAP Levels Combined with Plasma CEA Levels Are Prognostic Biomarkers for Early-Clinical-Stage Patients of Colorectal Cancer

Table 3

Multivariate analyses of individual parameters for relationship with overall survival rate: Cox proportional-hazards model.

Variables	Single variable			Multivariable
	HR	95% CI		HR	95% CI
YAP (high)	2.128	1.349–3.356	0.001	1.714	1.068–2.752	0.026
Age (≥56 years)	1.009	0.983–1.036	0.495
Gender (female)	1.091	0.579–2.055	0.787
Tumor size (≥3 cm)	1.014	0.940–1.095	0.713
Differentiation (Y)	0.675	0.443–1.030	0.069
Dukes stage (C and D)	2.187	1.427–3.350	<0.001	1.843	1.162–2.753	0.002
Lymph metastases (Y)	1.728	0.898–3.327	0.102
LNR (≥28)	0.995	0.635–1.560	0.938
Remote metastasis (Y)	4.247	1.802–10.009	0.001	3.131	1.333–7.355	0.009
CEA (>5 ng/ml)	1.667	1.054–2.637	0.029	1.535	0.969–2.433	0.068
YAP(high) + CEA (>5 ng/ml)	5.063	1.797–14.265	<0.001	3.936	1.367–11.331	0.011

Abbreviations: HR, hazard radio; CI, confidence interval; LNR, lymph node ratio. Statistically significant ().