Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia

Table 2

Genotype and allele frequencies of MSX1, PAX9, and AXIN2 polymorphisms in the local population.

Polymorphism	Agenesis: all cases (N = 97), n	Controls (N = 99), n	Statistical analysis for genotypes	Statistical analysis for alleles
MSX1 rs12532 A/G
A/A	50	45	A/G + G/G vs A/A	G vs A
A/G	37	42	Chi-square = 0.5	Chi-square = 0.53
G/G	10	12
A	137	132	OR = 0.78	OR = 0.83
G	57	66
MSX1 rs8670 C/T
C/C	49	74	C/T + T/T vs C/C	T vs C
C/T	37	22	Chi-square = 11.24	Chi-square = 14.09
T/T	11	3
C	135	170	OR = 2.9	OR = 2.65
T	59	28
PAX9 rs61754301 C/T
C/C	97	99	C/T + T/T vs C/C	T vs C
C/T	0	0
T/T	0	0	NA	NA
C	194	198
T	0	0
PAX9 rs4904155 C/G
C/C	40	50	C/G + G/G vs C/C	G vs C
C/G	43	34	Chi-square = 1.34	Chi-square = 0.61
G/G	14	15
C	123	134	OR = 1.45	OR = 1.2
G	71	64
AXIN2 rs2240308 G/A
G/G	18	24	G/A + A/A vs G/G	A vs G
G/A	49	55	Chi-square = 0.63	Chi-square = 2.32
A/A	30	20
G	85	103	OR = 1.4	OR = 1.39
A	109	95

, highly significant; , significant; , not significant; NA, not available.