Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia

Table 3

Genotype and allele frequencies of MSX1, PAX9, and AXIN2 polymorphisms in frontal agenesis.

Polymorphism	Frontal agenesis (N = 42), n	Matched controls (N = 42), n	Statistical analysis for genotypes	Statistical analysis for alleles
MSX1 rs12532
A/G	25	15	A/G + G/G vs A/A	G vs A
A/A	13	20	Chi-square = 3.86	Chi-square = 3.89
A/G	4	7
G/G	63	50	OR = 0.37	OR = 0.49
A	21	34
G
MSX1 rs8670 C/T
C/C	20	36	C/T + T/T vs C/C	T vs C
C/T	17	6	Chi-square = 12.05	Chi-square = 15.08
T/T	5	0
C	57	78	OR = 6.6	OR = 6.15
T	27	6
PAX9 rs61754301
C/T	42	42	C/T + T/T vs C/C	T vs C
C/C	0	0
C/T	0	0	NA	NA
T/T	84	84
C	0	0
T
PAX9 rs4904155
C/G	18	22	C/G + G/G vs C/C	G vs C
C/C	20	14	Chi-square = 0.42	Chi-square = 0.02
C/G	4	6
G/G	56	58	OR = 1.46	OR = 1.11
C	28	26
G
AXIN2 rs2240308
G/A	7	15	G/A + A/A vs G/G	A vs G
G/G	23	21	Chi-square = 3.01	Chi-square = 4.03
G/A	12	6
A/A	37	51	OR = 2.77	OR = 1.96
G	47	33
A

, highly significant; , significant; , not significant; NA, not available.