A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

Figure 2

Multiple reaction monitoring (MRM) of a blank plasma (a); a plasma sample spiked with a standard mixture of SOR at its LLOQ level with ERL (IS) (b); plasma samples taken 1 h following SOR administration to rats (40 mg/kg) with either water (control group) or different types of tested ITs (c).

(a)

(b)

(c)