A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

Table 1

Evaluation of the extraction recovery and matrix effect for the determination of SOR in rat plasma by the proposed UPLC-MS/MS method.

Concentration added (ng/mL)	Extraction recovery		Matrix effect
	Mean recovery (%) ±RSD	Er (%)	Mean recovery (%) ±RSD^a	Er (%)
2.5	92.68 ± 3.01	−7.32	92.45 ± 4.44	−7.55
7.5	91.24 ± 2.76	−8.67	97.67 ± 0.91	−2.33
200	100.57 ± 3.32	0.57	95.67 ± 2.26	−4.33
450	98.92 ± 2.01	−1.08	99.35 ± 0.58	−0.65

Mean recovery (%) ±RSD of six determinations. E_r (%): percentage relative error.