A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

Table 2

Evaluation of the intraday and interday accuracy and precision for the determination of SOR in rat plasma by the proposed UPLC-MS/MS method.

Concentration added (ng/mL)	Intraday (n = 6)		Interday (n = 18)
	Mean recovery (%) ±RSD	Er (%)	Mean recovery (%) ±RSD	Er (%)
2.5	94.86 ± 4.43	−5.14	95.73 ± 6.11	−4.27
7.5	96.63 ± 3.52	−3.37	93.41 ± 1.57	−6.59
200	98.79 ± 0.27	−1.21	96.87 ± 2.81	−3.13
450	97.97 ± 2.45	−2.03	99.10 ± 0.51	−0.90

Mean recovery (%) ±RSD of six determinations. E_r (%): percentage relative error.