A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Concentration spiked (ng/mL)</td><td class="align_center">Dilution fold</td><td class="align_center">Mean recovery (%) ±RSD</td><td class="align_center"><i>E</i><sub>r</sub> (%)</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left" rowspan="2">600</td><td class="align_center">1 : 2</td><td class="align_center">97.37 ± 1.67</td><td class="align_center">−2.63</td></tr><tr><td class="align_center">1 : 5</td><td class="align_center">97.10 ± 1.95</td><td class="align_center">−2.90</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Mean recovery (%) ±RSD of six determinations. <i>E</i><sub>r</sub> (%): percentage relative error.<br/></div></td></tr></table>

<div>Evaluation of the dilution integrity of SOR in rat plasma.</div>

BioMed Research International

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Table 3

Table 3: A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction 