A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

Table 4

Evaluation of the stability of SOR in rat plasma.

Stability	Concentration added (ng/mL)	Mean recovery (%) ±RSD
Autosampler stability (10°C, 56 h)	7.5	97.64 ± 1.87
	450	98.25 ± 3.11
Short-term stability (25°C, 6 h)	7.5	98.13 ± 2.39
	450	100.47 ± 2.72
Long-term stability (−30°C, 30 days)	7.5	97.54 ± 3.93
	450	95.87 ± 2.33
Freeze-thaw stability (−30°C, 3 cycles)	7.5	93.57 ± 1.68
	450	99.05 ± 2.39
Refrigerator (4°C, 3 months)	7.5	96.66 ± 3.78
	450	98.86 ± 1.39

Mean recovery (%) ±RSD of six determinations.