A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction

Table 5

Main pharmacokinetic parameters (mean ± SD) after oral administration of SOR to rats (n = 5).

	Group I; SOR (40 mg/kg)	Group II; SOR (40 mg/kg) + Lipton peach (IT 1)	Group III; SOR (40 mg/kg) + Lipton apricot (IT 2)	Group IV; SOR (40 mg/kg) + GPP (IT 3)	Group V; SOR (40 mg/kg) + TAZA tazoberry (IT 4)	Group VI; SOR (40 mg/kg) + Rauch (IT 5)	Group VII; SOR (40 mg/kg) + PASHA (IT 6)
Cmax (ng/mL)	34.67 ± 2.21	38.93 ± 4.82	37.83 ± 4.29	37.13 ± 3.56	28.78 ± 2.45	24.35 ± 2.78	19.95 ± 2.29
tmax (h)	2.74 ± 0.99	1.95 ± 0.74	2.52 ± 0.22	3.04 ± 0.72	2.50 ± 0.57	2.98 ± 0.31	3.31 ± 0.72
t½ (h)	36.48 ± 2.46	85.34 ± 3.71	42.90 ± 2.73	39.76 ± 2.86	107.22 ± 6.53	40.67 ± 1.95	62.72 ± 3.02
AUC0-t (ng·h/mL)	659.50 ± 45.64	487.41 ± 29.15	448.61 ± 24.76	408.43 ± 34.61	439.43 ± 48.17	384.75 ± 27.93	44.03 ± 42.84
AUC0-∞ (ng·h/mL)	1093.86 ± 98.64	1438.29 ± 147.24	761.61 ± 23.87	655.14 ± 36.28	1477.05 ± 221.41	644.14 ± 36.29	1116.53 ± 133.15
AUMC0-t (ng·h/mL)	12095.06 ± 1062.69	9813.53 ± 753.59	7432.71 ± 955.17	6125.81 ± 755.53	8474.67 ± 777.36	6562.05 ± 543.03	9843.53 ± 947.78
AUMC0-∞ (ng·h/mL)	52579.53 ± 1853.53	165795.6 ± 25471.07	42731.1 ± 2039.52	32883.51 ± 1887.29	224631.6 ± 25471.07	36043.20 ± 2846.87	98498.35 ± 977.33
MRT0-t (h)	18.67 ± 0.92	18.72 ± 1.05	16.88 ± 0.55	15.21 ± 0.94	18.42 ± 0.80	18.22 ± 1.06	20.61 ± 1.24
MRT0-∞ (h)	52.52 ± 4.44	114.43 ± 12.49	55.93 ± 6.26	50.13 ± 0.79	149.91 ± 24.53	56.46 ± 5.16	88.36 ± 8.68
CL (L/h/kg)	36.04 ± 4.88	27.77 ± 1.43	52.38 ± 2.80	60.83 ± 8.91	26.48 ± 3.08	63.68 ± 5.91	35.86 ± 4.87
λz (h^−1)	0.0184 ± 0.0032	0.0083 ± 0.0007	0.0161 ± 0.0024	0.0176 ± 0.0052	0.0065 ± 0.0017	0.0176 ± 0.0071	0.0113 ± 0.0029
Vd (mL/kg)	1.96 ± 0.77	3.39 ± 0.33	3.23 ± 0.68	3.51 ± 0.78	4.18 ± 0.87	3.61 ± 1.14	3.24 ± 0.64

Significant difference as compared with group I ().