D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity

<div>Structures of some CPT-related anticancer agents acting as topoisomerase I inhibitors. (a) Camptothecin. (b) Luotonin A. (c) Topotecan. (d) Irinotecan.</div>

BioMed Research International

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Figure 1

Figure 1: D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 

Figure 1 | D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 